The Clinical Question Crohn’s disease is notorious for its unpredictable cycle of remission and relapse. While many patients can achieve a period of clinical inactivity, maintaining that status is a persistent challenge in gastroenterology. Traditional maintenance therapies, such as mesalamine or corticosteroids, are not always effective or well-tolerated over the long term. Fish oil has […]
Middleton et al., 2018. Omega-3 fatty acid addition during pregnancy
Clinical Review: Omega-3 Fatty Acid Addition During Pregnancy The Clinical Question Preterm birth (delivery before 37 weeks) remains a leading cause of perinatal mortality and long-term morbidity in children worldwide. While advances in neonatal care have improved survival rates, preventing preterm labour remains a significant obstetric challenge. Observational data has long suggested a link between […]
West et al., 2010. Eicosapentaenoic acid reduces polyp number & size in familial adenomatous polyposis
The Clinical Question: Managing Post-Colectomy Risk in FAP Patients with familial adenomatous polyposis (FAP) face a lifelong battle against colorectal cancer. While the standard of care is a prophylactic colectomy to remove the primary risk, many patients undergo an ileorectal anastomosis to preserve bowel function. This leaves a rectal remnant that remains highly susceptible to […]
Synopsis: Characterizing Pediatric Familial Adenomatous Polyposis Colectomy in the United States
1.0 Introduction and Rationale Familial Adenomatous Polyposis (FAP) is an inherited syndrome characterized by the development of numerous adenomatous polyps in the colorectum, often beginning in childhood and adolescence. The clinical implications of FAP are profound; if left untreated, the polyps invariably undergo malignant transformation, leading to colorectal cancer by a mean age of 39 […]